6-hydroxydopamine相关论文
Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a ......
The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR;Paeonia Suffruticosa Andrews (Paeoniaceae)] e......
Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model o
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The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat
The excitability of dopaminergic neurons in the substantia nigra pars compacta(SNc)that supply the striatum with dopamin......
Aim: An attempt has been made to explore the neuroprotective and antitremor effect of baicalein on neurons against exper......
Dysfunction of Cholinergic Anti-Inflammatory Pathway Mediates Gastric Inflammation in 6-OHDA rat mod
Introduction: Vagus nerve regulates intestinal inflammation via its principal neurotransmitter acetylcholine(ACh)interac......
Dose-dependent effects of 6-hydroxydopamine on refractive development and form-deprivation myopia in
Objective We recently reported that retinal dopamine(DA)levels are unaltered during the development of form-deprivation ......
Human Umbilical Cord-Derived Mesenchymal Stem Cells Protects Against Behavior Defects in a Rat Model
Objectives: Stem cells provide potential treatment for Parkinson s disease (PD).Since human umbilical cord mesenchymal s......
Tetrahydroxystibene glucoside protects dopaminergic neurons against 6-OHDA-induced neurotoxicity via
Parkinsons disease (PD) is a neurodegenerative disease characterized by a slow and progressive loss of dopamine (DA) neu......
AIM To investigate the effects and the underlying mechanism of Echinacoside (ECH) against 6-OHDA-induced injury in vitro......
Objective: to study the protective effect of MgSO4 on 6-hydroxydopamine(6-OHDA)induced neurotoxicity in SH-SY5Y cells,an......
EFFECTS OF ENDOGENOUS MELATONIN ON GLUTAMATE AND GABA RHYTHMS IN THE STRIATUM OF UNILATERAL 6-HYDROX
We have previously reported a time-dependent increase in melatonin (MLT) and decrease In dopamine (DA) in striatal dialy......
The role of retinal dopamine in C57BL/6 mouse refractive development as revealed by intravitreal adm
PURPOSE:While retinal dopamine (DA) has been long implicated in myopia development,current studies demonstrate that reti......
Dysfunctional autophagy often occurs during the development of neurodegenerative diseases,such as Parkinson’s disease,H......
目的探讨Ca2+/钙调蛋白依赖的蛋白激酶II(CaMKII)和Cav1.3在6-羟基多巴胺处理大鼠原代黑质多巴胺能神经元损伤中的作用。方法取出......
Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function, and also regulate p......
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We studied the effect of reduced glutathione on bone marrow stromal cells (BMSCs) treated with 6-hydroxydopamine (6-OHDA......
Objective:The present study was designed to investigate the effect of resveratrol (Res)on the motor function of Parkinso......
目的筛选合并代谢异常的帕金森病模型,为后续的相关实验研究提供理想的动物模型。方法SD雄性大鼠62只,随机分为损毁前脑内侧束(MFB......
BACKGROUND: To date, many 6-hydroxydopamine (6-OHDA)-lesioned rat models have been established by injecting 6-OHDA into ......
Establishing motor disorder mouse models of Parkinson disease Comparison of 6-hydroxydompamine and 1
BACKGROUND: At present, pathogenesis and mechanism of Parkinson disease (PD) are still unclear.Animal models of PD are e......
Dysfunctional autophagy often occurs during the development of neurodegenerative diseases, such as Parkinson’s disease,......
Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1
To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s......
,6-Hydroxydopamine-induced glutathione alteration occurs via glutathione enzyme system in primary cu
Aim: To define the role of enzymes involved in glutathione metabolism in 6-hydroxydopamine (6-OHDA)-induced glutathione ......
Bilobalide inhibits 6-OHDA-induced activation of NF-κB and loss of dopaminergic neurons in rat subst
Aim: To investigate the offect of bilobalide on the activation of NF-κB, and apoptasis of dopaminergic neurons induced ......
To study the effect of PD I administration on dopamine receptors (DR1, DR2 ) mRNAs expression in the lesioned striatum o......
Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the sub
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目的探讨帕金森病(PD)大鼠模型中脑线粒体的变化及硫辛酸的保护作用。方法 80只SD雄性大鼠,随机分为假手术组(20只)、模型组(60只)......
In the present study, PC12 cells induced by 6-hydroxydopamine as a model of Parkinson's Disease, were used to investigat......
Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the sub
Previous studies have shown that Zhichan powder elevated immunity and suppressed oxidation in mice. Rat models of Parkin......
目的 评价尿酸对6-羟基多巴胺致大鼠黑质纹状体系统多巴胺能神经元毒性的影响.方法 30只雄性SD大鼠,分为生理盐水组(10只)、100 mg......
目的 研究自噬在帕金森病(PD)细胞模型中的作用及可能的机制.方法 体外培养的PC12细胞加入6-羟基多巴(6-OHDA)诱导多巴胺能神经元......
Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigr......
《医用神经生物学》正式出版发行由韩济生、关新民主编，北京医科大学、同济医科大学、第二军医大学、白求恩医科大学、苏州医学院等......
目的观察镁对帕金森病(PD)大鼠黑质多巴胺神经元影响及其作用机制。方法应用6-羟基多巴胺(6-OHDA)制备偏侧PD大鼠模型后分为硫酸镁......
目的：改良6-羟基多巴胺（6-OHDA）立体定位注射法建立早期帕金森病（PD）大鼠模型。方法：40只雄性SD大鼠随机分为control组10只,model组30只;......
目的:探讨提高6-羟基多巴胺(6-OHDA)帕金森病(PD)大鼠模型成功率的方法,并对模型进行评价.方法:取SD大鼠90只,将6-OHDA立体定向微......
目的：探讨提高6－羟基多巴胺帕金森病大鼠模型成功率的方法，并从行为学、黑质多巴胺神经元形态学角度对模型进行评价。方法：取SD大鼠90......
目的探讨6-羟基多巴(6-OHDA)导致细胞毒性与谷氨酸(glutamate,Glu)递质水平和谷氨酸转运体的相关性.方法大鼠脑黑质内定位注射6-OH......
目的研究Necrostatin-1(Nec-1)对帕金森病(Parkinson’s disease,PD)细胞模型线粒体失能的影响,探讨Nec-1在帕金森病发病机制中的......
目的为拓宽6-OHDA损毁多巴胺能神经元所制备大鼠帕金森病模型的应用范围,采用多位点纹状体内注入6-OHDA的途径来制备模型.方法研究......
目的检测28醇对6-羟基多巴胺（6-OHDA）致帕金森病（PD）大鼠模型的作用。方法将大鼠分为假手术组（n=15）、模型组（n=15）、低剂量组（n=12）、中剂量......
目的探讨银杏叶提取物（Ginkgo bilobaextract,GBE）对6-羟基多巴胺（6-hydroxydopamine,6-OH-DA）诱导的PC12细胞氧化应激的保护作用及其......
兔瞬膜条件反射是以声音结合电刺激瞬膜建立起来的条件反射。本文观察了侧脑室注射6-羟基多巴胺(6-OHDA)对兔瞬膜条件反射的影响。......
